Initial Conformational Changes of Human Transthyretin under Partially Denaturing Conditions
نویسندگان
چکیده
منابع مشابه
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.
Insoluble protein fibrils resulting from the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer's disease, familial amyloid polyneuropathy, and senile systemic amyloidosis. The latter two diseases are associated with transthyretin (TTR) amyloid fibrils, which appear to form in the acidic partial dena...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2005
ISSN: 0006-3495
DOI: 10.1529/biophysj.105.059642